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KMID : 0370219980420050519
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Yakhak Hoeji
1998 Volume.42 No. 5 p.519 ~ p.526
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Renal Action of NG-Nitro-L-Arginine , Nitric Oxide Synthase Inhibitor , in Dog and Rabbit
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고석태/Ko ST
유강준/황명성/Yu KJ/Hwang MS
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Abstract
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This study was performed in order to investigate the effect of renal function of NG-nitro-L-arginine (L-NOARG), inhibitor of nitric oxide (NO) synthase, in dog and ra bbit. L-NOARG, when given intravenously in dogs, exhibited the decrease in urine flow (vol), renal plasma flow (RPF), osmolar clearance (Cosm) and amounts of sodium and potassium excreted in urine(ENa, EK). These renal functions of L-NOARG showed the same aspect in rabbit, too. L-NOARG, when administered into a renal artery, showed the same pattern as was obtained when given intravenously in both experimental and control kidney in dog. L-NOARG administered into the carotid artery showed the decrease in Vol, RPF, ENa, in a low doses that did not show any effect when given intravenously. Above results suggest that L-NOARG produces antidiuretic action in dog and rabbit, and these antidiuretic actions may be mediated by central action.
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KEYWORD
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